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Merck

SML3155

Sigma-Aldrich

Brincidofovir

≥98% (HPLC)

别名:

3-(Hexadecyloxy)propyl hydrogen ((S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yloxy)methylphosphonate, CMX 001, CMX001, Hexadecyloxypropyl-cidofovir

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About This Item

经验公式(希尔记法):
C27H52N3O7P
分子量:
561.69
MDL號碼:
分類程式碼代碼:
51111800
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear (Warmed)

儲存溫度

-10 to -25°C

生化/生理作用

Brincidofovir is an orally bioavailable prodrug of cidofovir with activity against pox viruses as well as CMV, HSV, and Varicella zoster.

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Carc. 2 - Repr. 2 - Skin Sens. 1

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Julio J Alvarez-Cardona et al.
Future microbiology, 15, 389-400 (2020-03-14)
Brincidofovir (BCV) is a lipid conjugate of cidofovir with good oral bioavailability, enabling optimal intracellular levels of the active drug. Lower rates of nephrotoxicity and myelotoxicity make it a favorable alternative. Despite a greater safety profile among pediatric hematopoietic cell transplant
R Anthony Vere Hodge et al.
Advances in pharmacology (San Diego, Calif.), 67, 1-38 (2013-07-28)
This review starts with a brief description of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), the clinical diseases they cause, and the continuing clinical need for antiviral chemotherapy. A historical overview describes the progress from the early
Erik De Clercq
Medicinal research reviews, 33(6), 1249-1277 (2013-03-16)
Prominent in the current stage of antiviral drug development are: (i) for human immunodeficiency virus (HIV), the use of fixed-dose combinations (FDCs), the most recent example being Stribild(TM); (ii) for hepatitis C virus (HCV), the pleiade of direct-acting antivirals (DAAs)

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