SML3111

ETP-47799

≥98% (HPLC)

• 别名: CDK8/19i-47799, CDK8/19i-CNIO-47799, ETP 47799, ETP47799, Lck-IN-1, N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
• 经验公式（希尔记法）: C₁₄H₁₅N₅
• CAS号: 923596-52-5
• 分子量: 253.30
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3
• InChI 密鑰: XTMROGQLIVGYKF-UHFFFAOYSA-N

说明

生化／生理作用

ETP-47799 is a potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor (CDK8/19 IC50 = 2.9/14.1 nM; CDK1/5/9 IC50 = 275/239/124 nM; CDK2/4/6/7 IC50 >1 μM; GSK3β IC50 = 3.14 μM) with additional potency against PDGFRα (IC50 = 3.5 nM). ETP-47799 ( 0.4 μM or 1.1 μM) induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs) with better efficiency than the commonly used MEK/GSK3 inhibitor cocktail (1μM PD0325901, 1.5μM CHIR 99021).

Potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor that induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable