SML3006

ICCB-19 Hydrochloride

≥98% (HPLC)

• 别名: N-Cycloheptyl-2-[(4,5-dihydro-1H-imidazol-2-yl)thio]acetamide hydrochloride
• 经验公式（希尔记法）: C₁₂H₂₁N₃OS · HCl
• CAS号: 1803605-68-6
• 分子量: 291.84
• MDL號碼: MFCD28145281
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(NC1CCCCCC1)CSC2=NCCN2.Cl

说明

生化／生理作用

ICCB-19 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. ICCB-19 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently ICCB-19 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable