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Merck
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文件

SML2991

Sigma-Aldrich

Ru265

≥95% (HPLC), powder, mitochondrial calcium uniporter inhibitor

别名:

Ru2(μ-N)(NH3)8Cl2]Cl3, trans,trans-Octaamminedichloro-μ-nitridodi-Ruthenium(3+) trichloride, Nitride, ruthenium complex

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About This Item

经验公式（希尔记法）:
Cl5H24N9Ru2
CAS号:
27056-01-5
分子量:
529.66
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

Ru265, ≥95% (HPLC)

品質等級

100

化驗

≥95% (HPLC)

形狀

powder

顏色

white to dark beige

溶解度

H2O: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

Cl[Ru](N)(N)(N)(N)n[Ru](N)(N)(N)(N)Cl

生化／生理作用

Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca2+] (mCa2+), but not cytosolic [Ca2+] (cCa2+) transient (50 ?M; HeLa) by blocking MCU-mediated mCa2+ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa2+ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal rat ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa2+ overload.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Joshua J Woods et al.
Angewandte Chemie (International ed. in English), 59(16), 6482-6491 (2020-02-11)
The mitochondrial calcium uniporter (MCU) is the ion channel that mediates Ca2+ uptake in mitochondria. Inhibitors of the MCU are valuable as potential therapeutic agents and tools to study mitochondrial Ca2+ . The best-known inhibitor of the MCU is the

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