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SML2705

Sigma-Aldrich

TP-008

≥98% (HPLC)

别名:

1-[2-(5-Chloro-2-fluorophenyl)-5-methyl-4-pyridinyl]-1,2-dihydro-2-oxo-3H -imidazo[4,5-c ]pyridine-3-acetamide, 2-(1-(2-(5-Chloro-2-fluorophenyl)-5-methylpyridin-4-yl)-2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)acetamide

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About This Item

经验公式（希尔记法）:
C20H15ClFN5O2
CAS号:
1976038-41-1
分子量:
411.82
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

生化／生理作用

SGC Frankfurt Pharma donated probe. TP-008 is a cell penetrant, potent and selective ALK4/5 ((activin-like kinase 4/5) dual inhibitor that potently inhibits SMAD2/3 phosphorylation in C2C12 cells. TP-008 exhibits significant cardiac toxicity in mice. It is compound 18 in BMCL 2016 paper.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Haixia Wang et al.
Bioorganic & medicinal chemistry letters, 26(17), 4334-4339 (2016-07-28)
Using SBDD, a series of 4-amino-7-azaindoles were discovered as a novel class of Alk5 inhibitors that are potent in both Alk5 enzymatic and cellular assays. Subsequently a ring cyclization strategy was utilized to improve ADME properties leading to the discovery

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