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Merck

SML2656

Sigma-Aldrich

TSQ

≥98% (HPLC)

别名:

6-Methoxy-8-p-toluenesulfonamido-quinoline, N-(6-Methoxy-8-quinolinyl)-4-methylbenzenesulfonamide

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About This Item

经验公式(希尔记法):
C17H16N2O3S
分子量:
328.39
MDL號碼:
分類程式碼代碼:
12171500
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=S(C1=CC=C(C)C=C1)(NC2=C3C(C=CC=N3)=CC(OC)=C2)=O

InChI

1S/C17H16N2O3S/c1-12-5-7-15(8-6-12)23(20,21)19-16-11-14(22-2)10-13-4-3-9-18-17(13)16/h3-11,19H,1-2H3

InChI 密鑰

HKRNYOZJJMFDBV-UHFFFAOYSA-N

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應用

Zn+ selective probe in the presence of Mg+ and Ca+.

生化/生理作用

TSQ (6-methoxy-8-p-toluenesulfonamido-quinoline) is a cell penetrant and specific fluorescent zinc sensor that preferentially accumulates in islet cells in a zinc content dependent manner. TSQ is commonly used to assess isolated islet purity.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Jeffrey W Meeusen et al.
Inorganic chemistry, 50(16), 7563-7573 (2011-07-22)
Zn(2+) is a necessary cofactor for thousands of mammalian proteins. Research has suggested that transient fluxes of cellular Zn(2+) are also involved in processes such as apoptosis. Observations of Zn(2+) trafficking have been collected using Zn(2+) responsive fluorescent dyes. A
Timothy M Horton et al.
Cell chemical biology, 26(2), 213-222 (2018-12-12)
Diabetes is a hyperglycemic condition characterized by pancreatic β-cell dysfunction and depletion. Whereas methods for monitoring β-cell function in vivo exist, methods to deliver therapeutics to β cells are lacking. We leveraged the rare ability of β cells to concentrate zinc to
Mohammad R Karim et al.
Metallomics : integrated biometal science, 9(4), 391-401 (2016-12-06)
Nitric oxide (NO) is both an important regulatory molecule in biological systems and a toxic xenobiotic. Its oxidation products react with sulfhydryl groups and either nitrosylate or oxidize them. The aerobic reaction of NO supplied by diethylamine NONOate (DEA-NO) with

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