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SML2295

Sigma-Aldrich

Dimethyoxy-etomidate

≥98% (HPLC)

别名:

(R)-ethyl 1-(1-(3,5-dimethoxyphenyl)ethyl)-1H-imidazole-5-carboxylate

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About This Item

经验公式（希尔记法）:
C16H20N2O4
CAS号:
2300142-82-7
分子量:
304.34
分類程式碼代碼:
12352200

化驗

≥98% (HPLC)

形狀

oil

顏色

colorless to light brown

儲存溫度

2-8°C

SMILES 字串

C[C@@H](N1C=NC=C1C(OCC)=O)C2=CC(OC)=CC(OC)=C2

生化／生理作用

Dimethyoxy-etomidate is a phenyl ring substituted etomidate analog.
Dimethyoxy-etomidate is a potent suppressor of adrenocortical steroid synthesis by inhibiting steroid 11β-hydroxylase. Dimethyoxy-etomidate is essentially divided of etomidate′s GABAA receptor positive modulatory and sedative-hypnotic activities.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Megan McGrath et al.
The Journal of pharmacology and experimental therapeutics, 364(2), 229-237 (2017-12-06)
Cushing's syndrome is characterized by the overproduction of adrenocortical steroids. Steroidogenesis inhibitors are mainstays of medical therapy for Cushing's syndrome; unfortunately, adverse side effects and treatment failures are common with currently available drugs. The general anesthetic induction agent etomidate is
Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
McGrath M, et al.
BMC Pharmacology & Toxicology, 20, 1-9 (2019)

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