推荐产品
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to beige
溶解度
H2O: 2 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
CCOC1=CC=C(S(N2CCN(CC)CC2)(=O)=O)C=C1C3=NN4C(C(N3)=O)=C(C)N=C4CCC.Cl
InChI
1S/C23H32N6O4S.ClH.3H2O/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28;;;;/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30);1H;3*1H2
InChI 密鑰
FBCDRHDULQYRTB-UHFFFAOYSA-N
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生化/生理作用
Vardenafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5). It is used clinically to treat erectile dysfunction.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - STOT RE 2
標靶器官
Cardio-vascular system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
European journal of heart failure, 19(3), 326-336 (2016-12-21)
Heart failure with preserved ejection fraction (HFpEF) has a great epidemiological burden. The pathophysiological role of cyclic guanosine monophosphate (cGMP) signalling has been intensively investigated in HFpEF. Elevated levels of cGMP have been shown to exert cardioprotective effects in various
Clinical science (London, England : 1979), 131(11), 1107-1121 (2017-02-16)
Chronic inflammation that progressively disrupts the lung tissue is a hallmark of cystic fibrosis (CF). In mice, vardenafil, an inhibitor of phosphodiesterase type 5 (PDE5), restores transepithelial ion transport and corrects mislocalization of the most common CF mutation, F508del-CFTR. It also
BJU international, 119(2), 325-332 (2016-10-21)
To evaluate the expression of the Rho/Rho-associated protein kinase (ROCK) pathway in the corpus cavernosum of patients with severe erectile dysfunction (ED) compared with healthy human corpus cavernosum, and to test the functional effects of two Rho kinase inhibitors (RKIs)
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