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Merck
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Key Documents

SML2083

Sigma-Aldrich

[Ala13]-Apelin-13 三氟乙酸盐

≥96% (HPLC)

别名:

(F13A)apelin-13, Apelin-13(F13A), Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala TFA, L-谷氨酰胺基-L-精氨酸基-L-脯氨酰基-L-精氨酸基-L-亮氨酰-L-丝氨酰-L-组氨酸基-L-赖氨酰糖基-L-脯氨酰基-L-甲硫酰基-L-脯氨酰基-L-丙氨酸TFA, QRPRLSHKGPMPA TFA, [Ala-13] apelin-13, 丙氨酸apelin-13

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About This Item

经验公式（希尔记法）:
C63H107N23O16S · xC2HF3O2
CAS号:
568565-11-7
分子量:
1474.73 (free base basis)
分類程式碼代碼:
51111800
NACRES:
NA.77

化驗

≥96% (HPLC)

形狀

powder

顏色

white to beige

運輸包裝

wet ice

儲存溫度

−20°C

生化／生理作用

（Ala13）-Apelin-13对应于在C末端（F13A）具有Phe-Ala取代的Apelin-13，并可在培养和体内动物研究中均作为针对apelin依赖性APJ功能的拮抗剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Frédéric Adam et al.
Blood, 127(7), 908-920 (2015-12-05)
Apelin peptide and its receptor APJ are directly implicated in various physiological processes ranging from cardiovascular homeostasis to immune signaling. Here, we show that apelin is a key player in hemostasis with an ability to inhibit thrombin- and collagen-mediated platelet
İlknur Birsen et al.
The journal of physiological sciences : JPS, 67(3), 373-385 (2016-07-03)
The objective of this study was to explore the role of apelin in the healing of gastric lesions induced by stress. Male Wistar rats were exposed to water immersion and restraint stress (WIRS) for 6 h with or without the apelin
Xue Han et al.
Atherosclerosis, 244, 1-8 (2015-11-19)
Vascular calcification (VC) is closely related to cardiovascular events in chronic kidney disease (CKD). Apelin has emerged as a potent regulator of cardiovascular function, but its role in VC during CKD remains unknown. We determined whether apelin plays a role
Dennis K Lee et al.
Endocrinology, 146(1), 231-236 (2004-10-16)
The apelin peptide is the endogenous ligand for the apelin G protein-coupled receptor. The distribution of the apelin peptides and receptor are widespread in the central nervous system and periphery, with reported roles in the hypothalamic-pituitary-adrenal axis, blood pressure regulation
Anne Drougard et al.
Antioxidants & redox signaling, 20(4), 557-573 (2013-07-25)
We have previously demonstrated that central apelin is implicated in the control of peripheral glycemia, and its action depends on nutritional (fast versus fed) and physiological (normal versus diabetic) states. An intracerebroventricular (icv) injection of a high dose of apelin
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