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SML2046

Sigma-Aldrich

ARM390

≥98% (HPLC)

别名:

AR-M 1000390, N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide

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About This Item

经验公式（希尔记法）:
C23H28N2O
CAS号:
209808-01-5
分子量:
348.48
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear (warmed)

儲存溫度

2-8°C

SMILES 字串

O=C(C1=CC=C(C(C2=CC=CC=C2)=C3CCNCC3)C=C1)N(CC)CC

InChI

1S/C23H28N2O/c1-3-25(4-2)23(26)21-12-10-19(11-13-21)22(18-8-6-5-7-9-18)20-14-16-24-17-15-20/h5-13,24H,3-4,14-17H2,1-2H3

InChI 密鑰

SMUGAZNLKPFBSB-UHFFFAOYSA-N

生化／生理作用

ARM390 in a δ-selective opioid receptor agonist derivative of SNC80. ARM390 leads to very low levels of receptor internalization, and does not induce acute desensitization of analgesic response compared to SNC80. ARM390 preferentially recruits arrestin 3 to the delta opioid receptor in mice.
low-internalizing δ opioid receptor agonist

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Amynah A Pradhan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(12), 3541-3551 (2016-03-26)
Ligand-specific recruitment of arrestins facilitates functional selectivity of G-protein-coupled receptor signaling. Here, we describe agonist-selective recruitment of different arrestin isoforms to the delta opioid receptor in mice. A high-internalizing delta opioid receptor agonist (SNC80) preferentially recruited arrestin 2 and, in
S Stevens Negus et al.
The journal of pain : official journal of the American Pain Society, 13(4), 317-327 (2012-03-20)
The delta opioid receptor agonist SNC80 produces both antinociceptive and antidepressant effects in rodents. This profile suggests that SNC80 may also reverse prodepressant effects of pain. Accordingly, this study compared SNC80 effects in complementary assays of pain-stimulated and pain-depressed behavior
Amynah A A Pradhan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(49), 16459-16468 (2010-12-15)
δ-Opioid receptors are G-protein-coupled receptors that regulate nociceptive and emotional responses. It has been well established that distinct agonists acting at the same G-protein-coupled receptor can engage different signaling or regulatory responses. This concept, known as biased agonism, has important

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