SML1821
Imidafenacin hydrochloride
≥95% (HPLC)
别名:
2-Methyl-α,α-diphenyl-1H-imidazole-1-butanamide hydrochloride, 4-(2-Methyl-1-imidazolyl)-2,2-diphenylbutanamide hydrochloride, 4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride, CID 6433090 hydrochloride, HY-B06626433090 hydrochloride, KRP-197 hydrochloride, ONO-8025 hydrochloride
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About This Item
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生化／生理作用
Imidafenacin exhibits anticholinergic properties. It also has potential therapeutic effects on prostatic hyperplasia.
Imidafenacin is a potent antimuscarinic agent that exhibits selectivity toward muscarinic M3 receptors with Kb of 0.317 nM. Imidafenacin is used for treating overactive bladder.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Naoki Aizawa et al.
The Journal of urology, 193(4), 1423-1432 (2014-09-16)
Imidafenacin and fesoterodine are used to treat overactive bladder. Imidafenacin, fesoterodine and its active metabolite 5-hydroxymethyl tolterodine are muscarinic receptor antagonists. It is believed that these agents act on afferent nerves in addition to smooth muscle. We investigated the effects
Masayuki Takeda et al.
Urology, 82(4), 887-893 (2013-08-21)
To evaluate the effects of add-on treatment with an anticholinergic (imidafenacin) on persistent overactive bladder (OAB) symptoms despite α-blocker (tamsulosin) treatment in patients with benign prostatic hyperplasia (BPH). Patients with BPH ≥50 years old, with urinary urgency at least once per
Shiori Kuraoka et al.
Journal of pharmacological sciences, 131(3), 184-189 (2016-07-20)
The present study aimed to directly characterize specific binding sites of tritium ([(3)H])-labeled imidafenacin, a new radioligand for labeling muscarinic receptors, in the bladder and other peripheral or central nervous tissues of rats. Muscarinic receptors in rat tissues were measured
Takanobu Yamazaki et al.
European journal of pharmacology, 791, 72-77 (2016-10-30)
Imidafenacin, an antimuscarinic agent for treating overactive bladder, has an antidiuretic effect, but the detailed mechanisms of action remain unclear. The cholinergic and vasopressin systems are known to interact, for example, in the suppression of vasopressin-induced water reabsorption through muscarinic
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