SML1645

SBI-0640756

≥98% (HPLC)

• 别名: 6-Chloro-3-[3-(5-fluoro-pyridin-3-yl)-acryloyl]-4-phenyl-1H-quinolin-2-one, SBI-756
• 经验公式（希尔记法）: C₂₃H₁₄ClFN₂O₂
• CAS号: 1821280-29-8
• 分子量: 404.82
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329825986
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 5 mg/mL, clear (warmed)
• 儲存溫度: 2-8°C
• SMILES 字串: FC1=CN=CC(/C=C/C(C2=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)NC2=O)=O)=C1
• InChI: 1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+
• InChI 密鑰: VVWGPQZBDQVQRC-RMKNXTFCSA-N

说明

生化／生理作用

SBI-0640756 is a potent inhibitor of eIF4G1 that disrupts the eIF4F complex assembly independently of mTOR. SBI-0640756 potently inhibits growth of BRAF-resistant and BRAF-independent melanomas including NRAS- and NF1-mutant melanomas. SBI-0640756 exhibits low toxicity against nontransformed fibroblasts. SBI-0640756 also suppressed AKT and NF-kB signaling.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable