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Merck
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SML1535

Sigma-Aldrich

DMH2

≥98% (HPLC)

别名:

4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, VU0364849

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About This Item

经验公式（希尔记法）:
C27H25N5O2
CAS号:
1206711-14-9
分子量:
451.52
分類程式碼代碼:
12352200
PubChem物質ID:
329825950
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 1 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

N1(CCOC2=CC=C(C(C=N3)=CN4C3=C(C5=CC=NC6=C5C=CC=C6)C=N4)C=C2)CCOCC1

InChI

1S/C27H25N5O2/c1-2-4-26-24(3-1)23(9-10-28-26)25-18-30-32-19-21(17-29-27(25)32)20-5-7-22(8-6-20)34-16-13-31-11-14-33-15-12-31/h1-10,17-19H,11-16H2

InChI 密鑰

DXLXRNZCYAYUED-UHFFFAOYSA-N

一般說明

DMH2 is a small molecule, which has ability to inhibit BMP type I receptors. The bone morphogenetic proteins (BMP) signal inhibition further decreases expression of Id proteins in lung cells.

生化／生理作用

DMH2 is a potent antagonist of the BMP receptor activin receptor-like kinase 3 (ALK3, BMPR-IA) that enhance liver regeneration. DMH2 potently inhibits BMP signaling and induced the greatest reduction of cell growth and expression of Id family members in H1299 non-small cell lung carcinoma cells.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Elaine Langenfeld et al.
Molecular cancer, 12(1), 129-129 (2013-10-29)
Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulation of inhibitor of differentiation protein/DNA binding proteins (Id1-3). Inhibition of BMP signaling decreases

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