SML1310
NSC756093
≥98% (HPLC)
别名:
4,9-Dihydro-4-(2-hydroxyethyl)-6-methoxy-9-phenyl-furo[3,4-b]quinolin-1(3H)-one, 4-(2-Hydroxyethyl)-6-methoxy-9-phenyl-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one
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所有图片(1)
About This Item
经验公式（希尔记法）:
C20H19NO4
CAS号:
分子量:
337.37
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
OCCN1C2=C(C(OC2)=O)C(C3=CC=CC=C3)C4=C1C=C(OC)C=C4
InChI
1S/C20H19NO4/c1-24-14-7-8-15-16(11-14)21(9-10-22)17-12-25-20(23)19(17)18(15)13-5-3-2-4-6-13/h2-8,11,18,22H,9-10,12H2,1H3
InChI 密鑰
SMEJQLRLHKWIFV-UHFFFAOYSA-N
生化／生理作用
NSC756093, a podophyllotoxin analog, is a potent and specific inhibitor of GBP1:PIM1 interaction that inhibits proliferation of paclitaxel resistant cancer cells. Apparently, NSC756093 stabilizes a conformation of GBP1 not suitable for binding to PIM1.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jing Zhao et al.
Frontiers in oncology, 9, 1494-1494 (2020-01-31)
The Guanylate binding proteins (GBPs) are a family of large GTPases and the most studied GBP family member is the guanylate binding protein 1 (GBP1). Earlier studies revealed that GBP1 expression was inflammatory cytokines-inducible, and most of the studies focused
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