SML1278

Geldanamycin Ready Made Solution

1 mg/mL, from Streptomyces hygroscopicus

• 别名: 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
• 经验公式（希尔记法）: C₂₉H₄₀N₂O₉
• CAS号: 30562-34-6
• 分子量: 560.64
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 生物源: Streptomyces hygroscopicus
• 品質等級: 200
• 形狀: DMSO solution
• 儲存條件: protect from light
• 濃度: 1 mg/mL
• 抗生素活性譜: neoplastics
• 作用方式: enzyme | inhibits
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
• InChI 密鑰: QTQAWLPCGQOSGP-KSRBKZBZSA-N

说明

一般說明

Chemical structure: benzenoid

應用

Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.

生化／生理作用

Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 188.6 °F
• 閃點（°C）: 87 °C