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SML1145

Sigma-Aldrich

ML303

≥98% (HPLC)

别名:

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol

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About This Item

经验公式（希尔记法）:
C21H16F3N3O2
CAS号:
1638211-04-7
分子量:
399.37
分類程式碼代碼:
12352202
PubChem物質ID:
329825679
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

CC1=NN(C2=CC=C(C(F)(F)F)C=C2)C3=NC=CC(C4=CC=C(O)C(OC)=C4)=C31

InChI

1S/C21H16F3N3O2/c1-12-19-16(13-3-8-17(28)18(11-13)29-2)9-10-25-20(19)27(26-12)15-6-4-14(5-7-15)21(22,23)24/h3-11,28H,1-2H3

InChI 密鑰

YBRHGNCGFMRGSV-UHFFFAOYSA-N

生化／生理作用

It belongs to the pyrazolopyridine family.
ML303 is a potent inhibitor (IC50 = 155 nM) of the influenza viral protien NS1. NS1 enhances virulence by inhibiting host cell immune responses, including the expression of IFN-b, and regulating synthesis, splicing and translation of viral RNA.
ML303 is a potent inhibitor of the influenza viral protien NS1.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
104M4702V

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Nícia Rosário-Ferreira et al.
International journal of molecular sciences, 21(4) (2020-02-27)
Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and between 290,000 and 650,000 people die from it according

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