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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
InChI
1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+
InChI 密鑰
SVJQCVOKYJWUBC-OWOJBTEDSA-N
應用
Tetrabromocinnamic acid (TBCA) has been used in protein-fragment complementation assay, in an approach to identify inhibitors of αsyn oligomerization.
生化／生理作用
Tetrabromocinnamic acid (TBCA) is a selective cell-permeable ATP-competitive casein kinase CK2 inhibitor with an IC50 of 110 nM, 2-fold selectivity over CK1, and with the advantage of being less active on DYRK1A (IC50 = 24.5 μM) than other CK2 inhibitors suh as DMAT. Elevated levels of CK2 are associated with many cancers and also with tau hyperphosphorylation and neuropathology found in Alzheimer′s disease and other neurodegenerative disorders. In prostate cancer cells TBCA reduced cell proliferation and caused G2/M cell cycle arrest. In isolated squid axoplasms, TBCA also blocked inhibition of fast axonal transport by Aβ oligomers.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
argeting ?-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies.
Moussaud S, et al.
Expert Opinion on Therapeutic Targets, 19(5), 589-603 (2015)
Thomas Theis et al.
Molecular neurobiology, 55(10), 8203-8215 (2018-03-10)
Glycosylation fine-tunes signal transduction of adhesion molecules during neural development and supports synaptic plasticity and repair after injury in the adult nervous system. One abundantly expressed neural glycan is LewisX (LeX). Although it is known that its expression starts at
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