SML0723

ML252

≥98% (HPLC)

• 别名: (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
• 经验公式（希尔记法）: C₂₀H₂₄N₂O
• CAS号: 1392494-64-2
• 分子量: 308.42
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: , light to dark purple
• 溶解度: DMSO: 25 mg/mL, clear
• 儲存溫度: 2-8°C

说明

生化／生理作用

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC₅₀ of 69 nM. ML252 is only slightly selective over KCNQ3 and KCNQ4 but is over 40-fold selective for KCNQ2 vs KCNQ1, unlike other KCNQ inbhibitors currently used. ML252 was also selective vs. >68 tested GPCRs, ion channels, and transporters. Potassium channel Kv7.2 has become a new target for Alzheimer′s Disease drug research because inhibiting it enhances acetylcholine release. SAR studies showed a small structural change from ethyl group to hydrogen resulted in a functional shift from antagonist to agonist activity (37, EC₅₀ of 170 nM), suggesting an interaction at a critical site for controlling KCNQ2 channel gating.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable