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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
2-8°C
SMILES 字串
CCS(=O)c1nc(cc(n1)C(F)(F)F)-c2cccc(OCc3ccccc3)c2
InChI
1S/C20H17F3N2O2S/c1-2-28(26)19-24-17(12-18(25-19)20(21,22)23)15-9-6-10-16(11-15)27-13-14-7-4-3-5-8-14/h3-12H,2,13H2,1H3
InChI 密鑰
NTDFYGSSDDMNHI-UHFFFAOYSA-N
生化／生理作用
BETP是GLP-1受体的一种正变构调节剂，在弱GLP-1代谢产物GLP-1（9-36）存在的情况下可增强胰岛细胞中cAMP的积累和葡萄糖依赖性胰岛素的释放。BETP对内源性GLP-1受体配体GLP-1（7-36）具有累加作用。
BetP是一种三聚Na+偶联的甜菜碱同向转运蛋白。BetP属于甜菜碱-胆碱-肉碱转运蛋白（BCCT）家族。它可根据细胞质K+浓度而控制转运活性。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Lipid-protein interactions in the regulated betaine symporter BetP probed by infrared spectroscopy.
Guler G, et al.
The Journal of Biological Chemistry, 291(9), 4295-4307 (2016)
Khyati Girdhar et al.
Journal of biomolecular structure & dynamics, 37(15), 3976-3986 (2018-10-10)
The glucagon-like peptide-1 receptor (GLP-1R) is a well-known target of therapeutics industries for the treatment of various metabolic diseases like type 2 diabetes and obesity. The structural-functional relationships of small molecule agonists and GLP-1R are yet to be understood. Therefore
Locating an extracellular K+-dependent interaction site that modulates betaine-binding of the Na+-coupled betaine symporter BetP.
Ge L, et al.
Proceedings of the National Academy of Sciences of the USA (2011)
C Weston et al.
British journal of pharmacology, 171(15), 3651-3665 (2014-04-10)
The glucagon-like peptide 1 (GLP-1) receptor performs an important role in glycaemic control, stimulating the release of insulin. It is an attractive target for treating type 2 diabetes. Recently, several reports of adverse side effects following prolonged use of GLP-1
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