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化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to beige
溶解度
DMSO: ≥5 mg/mL (warmed)
儲存溫度
room temp
SMILES 字串
Cl.CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1
InChI
1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
InChI 密鑰
XZKWIPVTHGWDCF-KUZYQSSXSA-N
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應用
Amorolfine hydrochloride has been used as an antifungal agent.
生化／生理作用
Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.
Amorolfine hydrochloride is a potential for treating onychomycosis infected nails by topical application. A 5% solution combination with fluconazole is effective on sensitive fungus in fingernail onychomycosis.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Amorolfine
Haria M and BrysonHM
Drugs, 49(1), 103-120 (1995)
Production of Trichophyton rubrum microspores in large quantities and its application to evaluate amorolfine/azole compound interactions in vitro
Laurent A and Monod M
Mycoses, 60(9), 581-586 (2017)
A randomized, double-blind study of amorolfine 5\% nail lacquer with oral fluconazole compared with oral fluconazole alone in the treatment of fingernail onychomycosis
Chandra S, et al.
Indian Journal of Dermatology, 64(4), 253-253 (2019)
Yuji Tabata et al.
Antimicrobial agents and chemotherapy, 60(2), 1035-1039 (2015-12-09)
Fungal nail infection (onychomycosis) is a prevalent disease in many areas of the world, with a high incidence approaching 23%. Available antifungals to treat the disease suffer from a number of disadvantages, necessitating the discovery of new efficacious and safe
Sho Takahata et al.
Antimicrobial agents and chemotherapy, 60(2), 873-880 (2015-11-26)
Despite the existing treatment options for onychomycosis, there remains a strong demand for potent topical medications. ME1111 is a novel antifungal agent that is active against dermatophytes, has an excellent ability to penetrate human nails, and is being developed as
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