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SML0234

Sigma-Aldrich

Mitiglinide calcium

≥98% (HPLC)

别名:

(aS,3aR,7aS)-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calcium salt, KAD 1229, Mitiglinide hemicalcium salt, S 21403, [2(S)-cis]-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calclium salt

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About This Item

经验公式（希尔记法）:
C19H24NO3·0.5Ca
CAS号:
145525-41-3
分子量:
334.44
MDL號碼:
MFCD09955408
分類程式碼代碼:
12352200
PubChem物質ID:
329825247
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D +5 to +9° (c=1, MeOH)

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: ≥10 mg/mL at warmed to 60 °C

儲存溫度

room temp

SMILES 字串

O=C(C[C@H](Cc1ccccc1)C(=O)O[Ca]OC(=O)[C@H](CC(=O)N2C[C@H]3CCCC[C@H]3C2)Cc4ccccc4)N5C[C@H]6CCCC[C@H]6C5

InChI

1S/2C19H25NO3.Ca/c2*21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14;/h2*1-3,6-7,15-17H,4-5,8-13H2,(H,22,23);/q;;+2/p-2/t2*15-,16+,17-;/m00./s1

InChI 密鑰

PMRVFZXOCRHXFE-FMEJWYFOSA-L

生化／生理作用

Mitiglinide is a drug for the treatment of type 2 diabetes. It is a highly selective KATP channel antagonist Mitiglinide is a hypoglycemic agent that closes adenosine triphosphate (ATP)–sensitive potassium channels (KATP channel s) in the pancreatic β-islet cells.

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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H Konya et al.
The Journal of international medical research, 37(6), 1904-1912 (2010-02-12)
This study investigated the effects of mitiglinide in 16 patients with type 2 diabetes mellitus treated with 30 mg/day mitiglinide, divided into three doses given just before each meal, for approximately 12 months. A 450 kcal meal tolerance test was
Jin Ah Jung et al.
Clinical drug investigation, 32(12), 799-804 (2012-10-27)
In the treatment of diabetes mellitus, combined drugs with different mechanisms of action can be effective when adequate glycaemic control is difficult with monotherapy. A fixed-dose combination (FDC) tablet of mitiglinide and metformin has been developed as a second-line treatment
L Jin et al.
Arzneimittel-Forschung, 62(1), 40-45 (2012-02-15)
A sensitive and specific method was developed and validated for the determination of mitiglinide in plasma using LC-MS/MS. The effect of gemfibrozil on the pharmacokinetics of orally administered mitiglinide in rats was investigated. The validated method in positive electrospray ionization
Hind Hadi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 895-896, 131-136 (2012-04-17)
A hollow fiber liquid phase microextraction (HF-LPME) in conjunction with reversed phase HPLC-UV method was developed for the extraction and determination of trace amounts of the antidiabetic drug, mitiglinide (MIT) in biological fluids. The drug was extracted from 10 mL
Haley M Phillippe et al.
The Annals of pharmacotherapy, 44(10), 1615-1623 (2010-09-16)
To review the pharmacology, pharmacokinetics, efficacy, and safety of mitiglinide, a rapid-acting insulin secretion-stimulating agent to determine its potential role in therapy for the treatment of type 2 diabetes mellitus. A MEDLINE search (1966-May 2010) was conducted for English-language, human
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