SML0213

MC2050 hydrate

≥98% (HPLC)

• 别名: 2-[2-(4-(2-pyridyl)-1-piperazinyl)ethylsulfanyl]-3H-quinazolin-4-one dihydrochloride hydrate
• 经验公式（希尔记法）: C₁₉H₂₁N₅OS·2HCl · xH₂O
• 分子量: 440.39 (anhydrous basis)
• MDL號碼: MFCD21608523
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825234
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: H₂O: ≥5 mg/mL at warmed to 60 °C
• 儲存溫度: 2-8°C
• SMILES 字串: O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14
• InChI: 1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2
• InChI 密鑰: LMZZPRHHBPFDGE-UHFFFAOYSA-N

说明

應用

MC2050 hydrate may be used in cell signaling studies.

生化／生理作用

MC2050 is a PARP-1 inhibitor

MC2050 is a water-soluble PARP-1 inhibitor. The IC₅₀ for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

特點和優勢

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable