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Merck
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SML0176

Sigma-Aldrich

Z36

≥98% (HPLC)

别名:

(Z)-5-Fluoro-1-(3′-dimethylamino)propyl-3-[(5′-methoxyindol-3-ylidene)methyl]-indolin-2-one, 1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one

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About This Item

经验公式（希尔记法）:
C23H24FN3O2
CAS号:
1243148-19-7
分子量:
393.45
分類程式碼代碼:
12352200
PubChem物質ID:
329825205
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

light yellow to dark yellow

溶解度

DMSO: ≥15 mg/mL

儲存溫度

−20°C

SMILES 字串

COc1ccc2[nH]cc(\C=C3/C(=O)N(CCCN(C)C)c4ccc(F)cc34)c2c1

InChI

1S/C23H24FN3O2/c1-26(2)9-4-10-27-22-8-5-16(24)12-19(22)20(23(27)28)11-15-14-25-21-7-6-17(29-3)13-18(15)21/h5-8,11-14,25H,4,9-10H2,1-3H3/b20-11-

InChI 密鑰

CQNOITUXWKRVMB-JAIQZWGSSA-N

應用

Z36 may be used to study cell signaling that results in autophagy.

生化／生理作用

Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux.
Z36 is a Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Jian Lin et al.
Autophagy, 5(3), 314-320 (2009-02-27)
Inhibition of Bcl2 family proteins Bcl-X(L) and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. Here we report a novel Bcl-X(L) inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not

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