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主要文件

SCP0136

Endothelin β Receptor Antagonist IRL 1038

Name: Endothelin β Receptor Antagonist IRL 1038
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₆₈H₉₂N₁₄O₁₅S₂

分子量:

1409.67

分類程式碼代碼:

12352200

NACRES:

NA.32

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Slide 1 of 1

1 of 1

Sigma-Aldrich

RAB0460

人TGF-β 1 ELISA试剂盒

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥67%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp

應用

IRL-1038 is used as a specific endothelin-B receptor (ET(B)-R) antagonist/blocker.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Effects of specific endothelin-1 receptor antagonists on proliferation and fibronectin production of glomerular mesangial cells stimulated with Angiotensin II.

Hung-Tien Kuo et al.

The Kaohsiung journal of medical sciences, 22(8), 371-376 (2006-08-17)

Angiotensin II (Ang-II) is a potent vasoactive hormone, which plays an important role in the pathogenesis of glomerulosclerosis. Ang-II activates many cytokine systems in the kidney. Recent studies indicate that Ang-II is closely related to the activation of the endothelin-1

Regulation of vasopressin secretion by ETA and ETB receptors in compartmentalized rat hypothalamo-neurohypophysial explants.

Noreen F Rossi

American journal of physiology. Endocrinology and metabolism, 286(4), E535-E541 (2003-12-11)

The endothelins (ET) have been implicated in vasopressin (AVP) release in vivo and in vitro. The effects of ET in this system are complex, and the net AVP secretory response likely depends on a unique combination of ET isoform, ET

Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein.

Guo-lin Zhang et al.

Acta pharmacologica Sinica, 32(2), 223-229 (2011-02-05)

To investigate which endothelin receptors mediated isoproterenol (ISO)-induced downregulation of FKBP12.6/12 in cardiomyocytes and study whether argirhein, a novel compound containing rhein and L-arginine that has anti-inflammatory activity, could reverse the downregulation of FKBP12.6/12 induced by ISO. Neonatal rat cardiomyocytes

Endothelin receptor alterations in equine airway hyperreactivity.

Changaram S Venugopal et al.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 70(1), 50-57 (2006-03-22)

The purpose of this study was to evaluate the role of endothelin-1 (ET-1) and its receptors in the airway hyperreactivity of horses with obstructive pulmonary disease associated with summer pasture (SPAOPD). The right diaphragmatic lobe of the lung of 8

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