SBR00016

氨基蝶呤成品溶液

50 mg/mL in DMSO

• 别名: 4-氨基-PGA, 4-氨基叶酸
• 经验公式（希尔记法）: C₁₉H₂₀N₈O₅
• CAS号: 54-62-6
• 分子量: 440.41
• MDL號碼: MFCD00036692
• 分類程式碼代碼: 12352205
• NACRES: NA.76

属性

• 化驗: ≥85%
• 品質等級: 200
• 形狀: liquid
• 儲存條件: protect from light
• 濃度: 50 mg/mL in DMSO
• 溶解度: DMSO: 50 mg/mL
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: OC(CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=NC3=C(N)N=C(N)N=C3N=C2)C=C1)=O)=O
• InChI: 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)
• InChI 密鑰: TVZGACDUOSZQKY-UHFFFAOYSA-N

说明

生化／生理作用

Aminopterin is a synthetic derivative of pterin. It is used as a folic acid antagonist. It competitively inhibits dihydrofolate reductase (DHFR) and blocks tetrahydrofolate synthesis. This inhibition blocks DNA, RNA and protein synthesis.

Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.

Aminopterin was first administered for cancer therapy, as a drug targeting metabolism, specifically in pediatric leukemia. Later on it was demonstrated to be more potent yet more toxic than methotrexate.

安全信息

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H301,H341,H360FD
• 防範說明: P202 - P264 - P270 - P280 - P301 + P310 - P405
• 危險分類: Acute Tox. 3 Oral - Muta. 2 - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 188.6 °F
• 閃點（°C）: 87 °C