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SBR00011

Sigma-Aldrich

克拉霉素，现成溶液

50 mg/mL in DMSO

别名:

6-O-甲基红霉素

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About This Item

经验公式（希尔记法）:
C38H69NO13
CAS号:
81103-11-9
分子量:
747.95
MDL號碼:
MFCD00865140
分類程式碼代碼:
51101500
PubChem物質ID:
329824644
NACRES:
NA.85

描述

Ready Made Solution

品質等級

200

形狀

liquid

儲存條件

dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)

濃度

50 mg/mL in DMSO

顏色

colorless to faint yellow

抗生素活性譜

Gram-positive bacteria

作用方式

protein synthesis | interferes

儲存溫度

−20°C

InChI

1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

InChI 密鑰

AGOYDEPGAOXOCK-KCBOHYOISA-N

相关类别

一般說明

克拉霉素是一种大环内酯类抗生素，具有抗菌和抗炎作用。它是红霉素 A 的半合成 14 元衍生物，在酸性条件下抗降解。

應用

克拉霉素可用于-
  • 研究克拉霉素对动脉灌注兔左心室楔形制剂的 QT、Tp-e 和促心律失常事件的速率依赖性变化的影响
  • 表达 GFP（绿色荧光蛋白）的寄生虫的培养靶向顶质体，以进一步进行显微镜分析
  • NAB741 与克拉霉素在微量滴定板中的协同作用研究。

生化／生理作用

大环内酯类，如克拉霉素，通过与 50S 核糖体亚基结合，阻止细菌中的蛋白质合成。它还与其他核糖体蛋白结合，并阻止肽-dyl-tRNA 的易位。在难治性哮喘患者中，它能够调节白细胞介素 8（IL-8） 的水平，以及中性粒细胞在肺中的积聚和活化。因此，它可能被用作哮喘的附加疗法，以减少非嗜酸性气道炎症。

包裝

2ML

其他說明

保存于密闭容器内，置于干燥通风处。储存类别（TRGS 510）：可燃液体

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

188.6 °F

閃點（°C）

87 °C

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