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Merck
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主要文件

SAB5900405

Sigma-Aldrich

Anti-Monkeypox virus/MPXV A29L Antibody (SAA0286)

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别名:

A29L, Monkeypox virus (MPXV),A29

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About This Item

分類程式碼代碼:
12352203

生物源

mouse

品質等級

重組細胞

expressed in CHO cells

共軛

unconjugated

抗體表格

affinity purified immunoglobulin

無性繁殖

SAA0286, recombinant monoclonal

形狀

liquid

分子量

150 kDa

物種活性

monkeypox virus

濃度

1 mg/mL

技術

ELISA: 1:2000-1:4000
neutralization: 0.01-10 μg/mL

顏色

colorless

pH值

7.4

同型

IgG2a, kappa

Protein ID登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

-65 to -96°C

目標翻譯後修改

unmodified

一般說明

Anti-Monkeypox virus/MPXV A29L Antibody, clone SAA0286, is a monoclonal antibody produced in mouse. It is a single, highly specific, cloned antibody that is directed against the A29L protein of the monkeypox virus. It is composed of two heavy chains and two light chains, linked together by disulfide bonds. The heavy chains contain the antigen-binding region, and the light chains contain the constant region. The antigen-binding region is composed of two variable domains, which are responsible for recognizing and binding to the antigen.


Monkeypox virus (MPXV), like smallpox virus, belongs to the genus Orthopoxvirus. Its morphology is consistent with that of orthopoxvirus, with a brick-shaped or oval shape with rounded corners and a size of 200~400nm. Brick-shaped or oval-shaped, covered by a lipoprotein membrane or envelope, with two protein-containing side bodies in the middle, and a thick membrane core containing a large double-stranded DNA gene body. The genome of Mpox virus is a double-stranded DNA, about 197kb long, and the end of the genome contains an identical but opposite terminal inverted repeat sequence. The virus contains 190 open reading frames, 4 of which are located in terminal inverted repeats. The core proteins of monkeypox virus are A29L, A35R, B6R, M1R, H3L.

特異性

Monoclonal Anti-Monkeypox virus/MPXV A29L Antibody, clone SAA0286 binds to the A29L protein of the monkeypox virus, thereby inhibiting its ability to replicate and spread. This prevents the virus from causing infection and disease. The antibody also has the ability to neutralize the virus, which further prevents it from causing infection.

應用

ELISA,neutralization

包裝

100µg per vial / 1 mg per vial

儲存和穩定性

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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