生物源
rabbit
品質等級
材料
colorless
無性繁殖
4F10X4, monoclonal
形狀
liquid
分子量
75 kDa
物種活性
rat, human, rat
濃度
0.55 mg/mL
技術
western blot: 1:500 - 1:2000
顏色
colorless
同型
IgG
免疫原序列
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIIS
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MELK(9833)
一般說明
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
免疫原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MELK (Q14680).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
應用
WB
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 1
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