SAB5702280

Anti-LDL Receptor (LDLR) Antibody, clone 10K4L8, Rabbit Monoclonal

• 别名: LDLR,FH,FHC,LDLCQ2
• 分類程式碼代碼: 12352203
• NACRES: NA.46

属性

• 生物源: rabbit
• 品質等級: 100
• 材料: colorless
• 無性繁殖: 10K4L8, monoclonal
• 形狀: liquid
• 分子量: 100-160 kDa
• 物種活性: human, rat, rat
• 濃度: 1 mg/mL
• 技術: immunofluorescence: 1:50 - 1:200; western blot: 1:500 - 1:1000
• 顏色: colorless
• 同型: IgG
• 免疫原序列: TVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA
• UniProt登錄號: P01130
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... LDLR(3949)

说明

一般說明

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 761-860 of human LDL Receptor (LDLR) (NP_000518.1).

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

應用

WB, IF/ICC

安全信息

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H317,H411
• 防範說明: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• 危險分類: Aquatic Chronic 2 - Skin Sens. 1
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3