推荐产品
生物源
rabbit
品質等級
重組細胞
expressed in proprietary host
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
SP203, monoclonal
物種活性
human (tested)
技術
immunohistochemistry: 1:100
同型
IgG
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... ELANE(1991)
一般說明
Neutrophil elastase (NE) is a monomeric protein, encoded by the gene mapped to human chromosome 19p13.3. The protein has a molecular mass of 25 kDa and is mainly present in the neutrophil granules (located in the neutrophil cytoplasm).
Neutrophil elastase is a serine proteinase synthesized by promyelocytes and promonocytes. It is secreted by neutrophils to degrade extracellular matrix, and to destroy bacteria. It is used as a marker for myeloid leukemia cells.
免疫原
Synthetic peptide from human neutrophil elastase protein.
生化／生理作用
Neutrophil elastase (NE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. The encoded protein catalyzes the cleavage of tyrosyl-tRNA synthetase to produce cytokine domains that stimulates neutrophil chemotaxis. In addition, NE also facilitates the secretion of the neutrophil chemoattractant, interleukin-8 from endothelial cells.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Franz von Nussbaum et al.
ChemMedChem, 11(2), 199-206 (2015-09-04)
Human neutrophil elastase (HNE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. Overshooting high HNE activity is the consequence of a disrupted protease-antiprotease balance. Accordingly, there has been an intensive search for potent
Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis
Horwitz M, et al.
Nature Genetics, 23(4), 433-433 (1999)
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