推荐产品
生物源
rabbit
品質等級
重組細胞
expressed in proprietary host
共軛
unconjugated
抗體表格
tissue culture supernatant
抗體產品種類
primary antibodies
無性繁殖
SP6, monoclonal
物種活性
human (tested)
物種活性（以同源性預測）
bovine
技術
immunohistochemistry: 1:200
同型
IgG
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... MKI67(4288)
一般說明
Ki-67 is a nuclear protein, which is expressed in the proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.
The gene marker of proliferation Ki-67 (MKI67), spanning 15 exons, is mapped to human chromosome 10q26.2. The encoded protein contains phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal. It possesses 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.
免疫原
Synthetic peptide from C-terminus of human Ki-67 protein.
應用
Anti-KI-67 antibody, Rabbit monoclonal has been used in immunohistochemistry.
生化／生理作用
Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, functions as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered to be a potent cell proliferation marker.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Madhavi Joshi et al.
Behavioural brain research, 372, 112029-112029 (2019-06-14)
Hypoglycemia induced brain injury poses a major setback to optimal blood glucose regulation during diabetes. It causes irreversible injury in several brain regions culminating in improper function. Neuregulin 1 and ErbB receptors are involved in regeneration during adulthood as well
Stromal SPOCK1 supports invasive pancreatic cancer growth.
Veenstra V L, et al.
Molecular Oncology, 11(8), 1050-1064 (2017)
Janneke F Linnekamp et al.
Cancers, 13(10) (2021-06-03)
DNA hypermethylation is common in colon cancer. Previously, we have shown that methylation of WNT target genes predicts poor prognosis in stage II colon cancer. The primary objective of this study was to assess whether pre-operative treatment with decitabine can
CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma.
Tu M, et al.
Molecular Medicine Reports, 15(4), 1713-1721 (2017)
The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system.
Chaverra M, et al.
Disease models & mechanisms, 10(5), 605-618 (2017)
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