推荐产品
生物源
rabbit
品質等級
重組細胞
expressed in proprietary host
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
SP162, monoclonal
物種活性
human (tested)
物種活性（以同源性預測）
rat, chicken, rabbit, mouse, pig, bovine, dog
技術
flow cytometry: 1:150
immunoblotting: 1:150
immunohistochemistry: 1:150
同型
IgG
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... CD3E(916)
一般說明
CD3E (CD3e molecule) gene is mapped to human chromosome 11q23.3. This gene encodes fora subunit of T-cell regulator (TCR) protein complex. It possesses IgG (immunoglobulin G)-like extracelluar domain at the N-terminal, a transmembrane domain, a peptide bridge and an immunoreceptor tyrosine-based activation motif (ITAM) towards the cytoplasm. The protein also contains basic residue-rich sequence (BRS).
This antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells. It stains human T cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. This antibody is suitable for staining normal and neoplastic T cells in formalin-fixed, paraffin-embedded tissues.
免疫原
Synthetic peptide corresponding to internal region of the epsilon chain of human CD3 protein.
應用
Anti-CD3 antibody, Rabbit monoclonal has been used in immunohistochemistry.
生化／生理作用
CD3E (CD3e molecule) gene is associated with actin cytoskeletal rearrangement, through activation of a number of signaling pathways. CD3E is essential for membrane binding of T-cell regulator (TCR) protein complex.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Evidence for inducible recruitment of Wiskott-Aldrich syndrome protein to T cell receptor-CD3 complex in Jurkat T cells
Paensuwan P, et al.
Asian Pacific Journal of Allergy and Immunology / Launched by the Allergy and Immunology Society of Thailand, 33(3) (2015)
SnapShot: forkhead transcription factors II
Tuteja G and Kaestner KH
Cell, 131(1), 192-192 (2007)
Advances in Intracellular Space Research and Application, 254-254 (2013)
Ionic CD3- Lck interaction regulates the initiation of T-cell receptor signaling
Li L, et al.
Proceedings of the National Academy of Sciences of the USA, 114(29), E5891-E5899 (2017)
The T Cell Receptor FactsBook, 21-21 (2001)
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