推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous glycerol solution
分子量
antigen predicted mol wt 160 kDa
物種活性
rat, mouse, human
濃度
1 mg/mL
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
rat ... Slc12a1(25065)
一般說明
Solute carrier family 12 member 1 (SLC12A1) is a Na+-K+-Cl- transporter and it is expressed in the thick ascending loop of kidneys in rats. The gene ID of the protein is 25065.
特異性
Detects ~160 kDa.
免疫原
AA109 to 129 of the rat sequence
生化／生理作用
Solute carrier family 12 member 1 (SLC12A1) functions in water reabsorption in the kidneys.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
PBS, 50% glycerol, and 0.09% sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Kazuko Itoh et al.
Biochemical and biophysical research communications, 453(3), 356-361 (2014-09-30)
Sodium reabsorption via Na-K-2Cl cotransporter 2 (NKCC2) in the thick ascending limbs has a major role for medullary osmotic gradient and subsequent water reabsorption in the collecting ducts. We investigated intrarenal localization of three isoforms of NKCC2 mRNA expressions and
Hyperphosphorylation of Na-K-2Cl cotransporter in thick ascending limbs of Dahl salt-sensitive rats.
Gustavo R Ares et al.
Hypertension (Dallas, Tex. : 1979), 60(6), 1464-1470 (2012-10-31)
Salt-sensitive hypertension involves a renal defect preventing the kidney from eliminating excess NaCl. The thick ascending limb of Henle loop reabsorbs ≈ 30% of filtered NaCl via the apical Na-K-2Cl cotransporter (NKCC2). Higher NKCC2 activity and Cl reabsorption have been
Yanting Chen et al.
Frontiers in physiology, 12, 642274-642274 (2021-04-20)
Emerging evidence is showing that apelin plays an important role in regulating salt and water balance by counteracting the antidiuretic action of vasopressin (AVP). However, the underlying mechanism remains unknown. Here, we hypothesized that (pro) renin receptor (PRR)/soluble prorenin receptor
Aurélie Edwards et al.
American journal of physiology. Renal physiology, 307(2), F137-F146 (2014-05-23)
This study aims to understand the extent to which modulation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 differential splicing affects NaCl delivery to the macula densa. NaCl absorption by the thick ascending limb and macula densa cells is mediated by apical NKCC2.
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