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生物源
mouse
共軛
FITC conjugate
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
MEM-233, monoclonal
形狀
buffered aqueous solution
物種活性
human
技術
flow cytometry: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... CD80(941)
一般說明
Cluster of differentiation 80 (CD80), also called as lymphocyte activation antigen 7-1, is encoded by the gene mapped to human chromosome 3q13.33. The encoded protein is mainly expressed on antigen presenting cells such as, neutrophils, macrophages and dendritic cells.
The antibody MEM-233 reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
免疫原
Extracellular domain of human CD80 fused to human IgG1(Fc)
應用
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
生化／生理作用
Cluster of differentiation 80 (CD80) interacts with its ligand, co-stimulator ligand CD28 or with cytotoxic T-lymphocyte protein 4 (CTLA-4) and facilitates the regulation of CD4+ and CD8+ T cell activity. Elevated urinary CD80 excretion leads to Fabry disease. CD80, which is expressed on surface of dendritic cells acts as a key co-stimulatory molecule and induces second signal for the proper stimulation of cancer antigen-specific naive T cells.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Prediction of Radix Astragali Immunomodulatory Effect of CD80 Expression from Chromatograms by Quantitative Pattern-Activity Relationship.
Ng MC
BioMed Research International (2017)
Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population
Tang XF
The Journal of Investigative Dermatology, 133, 403-410 (2013)
Increased urinary CD80 excretion and podocyturia in Fabry disease
Trimarchi H
Journal of Translational Medicine, 14 (2016)
Diana Campioni et al.
Haematologica, 91(3), 364-368 (2006-03-15)
The immunophenotypic analysis of ex vivo-expanded mesenchymal stromal cells (MSC) has so far been confined to single or dual staining analysis in normal subjects. In this study, using a four-color cytofluorimetric protocol, we demonstrated that cultured MSC derived from the
Emily Charrier et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20(10), 1501-1507 (2014-08-17)
Plasmacytoid dendritic cells (pDCs) initiate both innate and adaptive immune responses, making them attractive targets for post-transplantation immunotherapy, particularly after cord blood transplantation (CBT). Toll-like receptor (TLR) agonists are currently studied for pDC stimulation in various clinical settings. Their efficacy
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