推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 55 kDa
物種活性
human, mouse, rat
濃度
~1 mg/mL
技術
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer473)
基因資訊
human ... AKT1(207)
rat ... Akt1(24185)
一般說明
AKT1 (AKT 丝氨酸/苏氨酸激酶1也称 v-akt 鼠胸腺瘤病毒致癌基因同系物1 和PKBα (蛋白激酶B)。它在肝脏、肌肉和脂肪细胞中表达。AKT1 基因位于人类染色体14q32上。它是AKT家族成员,具有氨基末端普列克底物蛋白同源 (pleckstrin homology,PH)结构域、短链α-螺旋连接子和羧基末端激酶结构域。
免疫原
在 Ser473 的磷酸化站点附近产生抗血清对抗来自人 Akt 的合成肽。
免疫原范围: 431-480
免疫原范围: 431-480
生化/生理作用
AKT1(AKT丝氨酸/苏氨酸激酶1)控制细胞的存活和攻击发病机制的抗凋亡作用几种癌症,因此,它在肿瘤发生中起角色至关重要的作用。在小鼠中,AKT1对正常发育至关重要。
特點和優勢
完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多。
外觀
兔 IgG 溶于磷酸盐缓冲盐水(不含 Mg2+ 和 Ca2+),pH7.4,150mM NaCl,0.02% 叠氮化钠和 50% 甘油中。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
其他客户在看
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population
Genetics and molecular research : GMR, 16(1) (2017)
Epigallocatechin-3-gallate-mediated cardioprotection by Akt/GSK-3?/caveolin signalling in H9c2 rat cardiomyoblasts
Journal of Biomedical Science (2013)
Journal of biomedical science, 20, 86-86 (2013-11-21)
Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evidence to support the cardioprotective effects of EGCg, it remains unclear whether EGCg affect trans-membrane signalling
OncoTargets and therapy, 10, 5685-5694 (2017-12-12)
Pre-B-cell leukemia homeobox 3 (PBX3) is upregulated in various malignancies; however, the role of PBX3 in cervical cancer (CC) is unknown. The purpose of this study was to explore the expression characteristics, clinicopathological significance, and molecular biological function of PBX3
Scientific reports, 6, 25960-25960 (2016-05-18)
The fatal disease amyotrophic lateral sclerosis (ALS) is characterized by the loss of somatic motor neurons leading to muscle wasting and paralysis. However, motor neurons in the oculomotor nucleus, controlling eye movement, are for unknown reasons spared. We found that
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