生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 44 kDa
物種活性
rat, mouse, human
濃度
~1 mg/mL
技術
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer359)
基因資訊
human ... NCF1(653361)
一般說明
Phospho-p47/ NCF1 (neutrophil cytosolic factor-1) codes for the p47phox subunit of the phagocyte NADPH oxidase (NOX2). It is a cytosolic factor. This gene is located with two pseudogenes (NCF1B and NCF1C). NCF1 is mapped to human chromosome 7q11.23.
免疫原
The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser359.
Immunogen Range: 331-380
Immunogen Range: 331-380
生化／生理作用
NCF1 (neutrophil cytosolic factor-1) is an important constituent of the phagocyte NADPH-oxidase system. The enzyme helps in the synthesis of microbicidal superoxide in phagocytes like neutrophil and plays a key role in host defense against microbial pathogens. A 2-bp GT deletion in exon 2 of the NCF1 gene results in chronic granulomatous disease (CGD).
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.
Zhao J, et al.
Nature Genetics, 49(3), 433-437 (2017)
Genomic structure of the human p47-phox (NCF1) gene.
Chanock SJ, et al.
Blood Cells, Molecules and Diseases, 26(1), 37-46 (2000)
A copy number variation in human NCF1 and its pseudogenes.
Brunson T, et al.
BMC Genetics, 11(1), 13-13 (2010)
Glaucy Rodrigues de Araújo et al.
Experimental biology and medicine (Maywood, N.J.), 242(3), 333-343 (2017-01-21)
Baccharis trimera, popularly known as "carqueja", is a native South-American plant possessing a high concentration of polyphenolic compounds and therefore high antioxidant potential. Despite the antioxidant potential described for B. trimera, there are no reports concerning the signaling pathways involved
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