推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 33 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pTyr15)
基因資訊
human ... CDK5(1020)
一般說明
Cyclin-dependent kinase 5 (CDK5) belongs to the CDKs family. Active CDK5 is present in pancreatic β cells, corneal epithelial cells and monocytes. This gene is mapped to human chromosome 7q36.
免疫原
The antiserum was produced against synthesized peptide derived from human CDK5 around the phosphorylation site of Tyr15.
Immunogen Range: 1-50
Immunogen Range: 1-50
生化／生理作用
Cyclin-dependent kinase 5 (CDK5) controls migration and neuronal plasticity. This protein participates in neuron migration, neurite outgrowth and support and synaptogenesis. It also helps in the development of lymphatic vessels. Suppressing Cdk5 promotes cell death of tumor-initiating cells.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China
Pan DH, et al.
European Journal of Medical Research, 21(1), 28-28 (2016)
Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway
Zhou X, et al.
Biochemical and Biophysical Research Communications, 492(3), 447-452 (2017)
Inhibition of Cdk5 induces cell death of tumor-initiating cells
Mandl MM, et al.
British Journal of Cancer, 116(7), 912-922 (2017)
Biological functions of CDK5 and potential CDK5 targeted clinical treatments
Shupp A, et al.
Oncotarget, 8(10), 17373-17382 (2017)
Chia-Yi Su et al.
Scientific reports, 9(1), 13703-13703 (2019-09-25)
Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in neuron and plays an important role in neuronal physiology. Increasing evidence also indicates that Cdk5 may contribute to malignant progression of some types of cancers; however, the underlying mechanism remains elusive. In
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