SAB4504190

Anti-phospho-HDAC6 (pSer²²) antibody produced in rabbit

affinity isolated antibody

• 别名: Anti-CPBHM, Anti-HD6, Anti-JM21, Anti-PPP1R90
• 分類程式碼代碼: 12352203
• NACRES: NA.41
• 共軛: unconjugated
• application: ELISA; IF; IHC; WB
• 無性繁殖: polyclonal
• 物種活性: human, rat, mouse
• citations: 5
• 技術: ELISA: 1:1000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 131 kDa
• 物種活性: human, rat, mouse
• 濃度: ~1 mg/mL
• 技術: ELISA: 1:1000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI登錄號: Q9UBN7
• UniProt登錄號: Q9UBN7
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pSer22)
• 基因資訊: human ... HDAC6(10013)

说明

一般說明

Histone deacetylases 6 (HDAC6) is encoded by the gene mapped to human chromosome Xp11.23. It belongs to the class IIb histone deacetylase family of enzymes, that remove acetyl groups from lysine residues. This protein is present mainly in cytosol.

免疫原

The antiserum was produced against synthesized peptide derived from human HDAC6 around the phosphorylation site of Ser22.

Immunogen Range: 7-56

生化／生理作用

Histone deacetylases 6 (HDAC6) is associated with various cellular processes such as regulation of microtubules, growth factor-induced chemotaxis, misfolded protein stress response, and tumor invasion. Increased expression of HDAC6 might promote tumorigenesis by upregulating the expression of c-myc. Overexpression of HDAC6 is seen in acute myeloid leukemia and some breast cancer patients. Oncogenic K-ras imparts suberoylanilide hydroxamic acid (SAHA) resistance via increasing HDAC6 and c-myc expression. HDAC6 controls cellular protective response against cytotoxic accumulation of toxic bioproducts. HDAC6 Inhibition is considered to be a potential therapeutic strategy for treating inflammatory breast cancer (IBC) patients. HDAC6 and acetylated α-tubulin play a vital role in regulation of adipocyte differentiation.

特點和優勢

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外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable