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Key Documents

SAB4504104

Sigma-Aldrich

Anti-phospho-PKD2 (pSer876) antibody produced in rabbit

affinity isolated antibody

别名:

Anti-HSPC187

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 96 kDa

物種活性

mouse, human, rat

濃度

~1 mg/mL

技術

ELISA: 1:60000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

phosphorylation (pSer876)

基因資訊

human ... PRKD2(25865)

一般說明

The protein kinase D2 (PRKD2) gene, mapped to human chromosome 4q21-23, codes for integral membrane protein polycystin-2. PRKD2 is a member of the serine/threonine protein kinase D (PRKD) family. It is characterized with two N-terminal cysteine-rich zinc finger domains involved in binding diacylglycerol (DAG) and phorbol esters, a central lipid/protein binding pleckstrin homology (PH) domain, and a C-terminal kinase domain. PRKD2 is mainly expressed in the endoplasmic reticulum (ER).

免疫原

The antiserum was produced against synthesized peptide derived from human PKD2 around the phosphorylation site of Ser876.

Immunogen Range: 829-878

生化/生理作用

Protein kinase D2 (PRKD2) is a novel, essential mediator of tumor cell-endothelial cell communication and a promising therapeutic target to inhibit angiogenesis in gastrointestinal cancers. Mutation in the gene leads to autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 might function as a component of intracellular channel complexes. PRKD2 influences CD8+ T cell-dependent immune responses. PKD2 facilitates cell migration and it is associated with the progression and maintenance of various malignancies. Increased expression of PKD2 is observed in various types of cancers including colorectal cancer, glioblastoma multiforme (GBM). CRT0066101 acts as an inhibitor for all the three protein kinase D isoforms. Therefore, it can be used as a therapeutic drug for PRKD2 induced carcinogenesis.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Nisha Durand et al.
Journal of clinical medicine, 5(2) (2016-02-06)
The Protein Kinase D (PKD) isoforms PKD1, PKD2, and PKD3 are effectors of the novel Protein Kinase Cs (nPKCs) and diacylglycerol (DAG). PKDs impact diverse biological processes like protein transport, cell migration, proliferation, epithelial to mesenchymal transition (EMT) and apoptosis.
Y Cai et al.
The Journal of biological chemistry, 274(40), 28557-28565 (1999-09-25)
PKD2, the second gene for the autosomal dominant polycystic kidney disease (ADPKD), encodes a protein, polycystin-2, with predicted structural similarity to cation channel subunits. However, the function of polycystin-2 remains unknown. We used polyclonal antisera specific for the intracellular NH(2)
I Plastira et al.
Journal of neuroinflammation, 14(1), 253-253 (2017-12-21)
Extracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1-6) and are indispensible for brain development and function of the nervous system. However, under neuroinflammatory conditions or brain damage, LPA levels increase, thereby inducing signaling cascades
T Mochizuki et al.
Science (New York, N.Y.), 272(5266), 1339-1342 (1996-05-31)
A second gene for autosomal dominant polycystic kidney disease was identified by positional cloning. Nonsense mutations in this gene (PKD2) segregated with the disease in three PKD2 families. The predicted 968-amino acid sequence of the PKD2 gene product has six
Ninel Azoitei et al.
Gut, 59(10), 1316-1330 (2010-08-25)
Tumour angiogenesis is crucially dependent on the communication between the tumour and the associated endothelium. Protein kinase D (PKD) isoenzymes mediate vascular endothelial growth factor-A (VEGF-A) induced endothelial cell proliferation and migration and are also highly expressed in various tumours.

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