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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 41 kDa
物種活性
mouse, rat, human
濃度
~1 mg/mL
技術
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pTyr322)
基因資訊
human ... MAPK14(1432)
一般說明
MAPK14 (mitogen-activated protein kinase 14) is a Ser/Thr kinase made of 90 to 360 residues. p38αMAPK is ubiquitously expressed. It is found in the cytosol, but it can translocate to the nucleus. This gene is located on human chromosome 6p21.31.
免疫原
The antiserum was produced against synthesized peptide derived from human p38 MAPK around the phosphorylation site of Tyr322.
Immunogen Range: 288-337
Immunogen Range: 288-337
生化／生理作用
MAPK14 (mitogen-activated protein kinase 14) participates in resistance of colon cancer cells to camptothecin-related drugs. This protein is required for the growth of embryos. This gene controls proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways. Polymorphism in MAPK14/p38a leads to deletion or overproduction of myelosuppressive cytokines and result in certain bone marrow failure syndromes.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
MAPK14 (mitogen activated protein kinase 14)
Porras A and Guerrero C
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)
MAPK14/p38? confers irinotecan resistance to TP53-defective cells by inducing survival autophagy.
Paillas S, et al.
Autophagy, 8(7), 1098-1112 (2012)
Beom Su Kim et al.
Biochemical and biophysical research communications, 450(4), 1333-1338 (2014-07-09)
Angiogenesis is an important biological process in tissue development and repair. Fucoidan has previously been shown to potentiate in vitro tube formation in the presence of basic fibroblast growth factor (FGF-2). However, the underlying molecular mechanism remains largely unknown. This
D R Mathern et al.
Mucosal immunology, 7(4), 995-1005 (2014-01-16)
The Notch-1 signaling pathway is responsible for homeostatic tight junction expression in vitro, and promotes barrier function in vivo in the RAG1-adoptive transfer model of colitis. In this study, we sought to determine the role of colonic Notch-1 in the
Xin-Juan Fan et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(10), 10487-10495 (2014-07-25)
Phosphorylated p38 (p-p38) played a pivotal role in the regulation of disease progression and correlated with tumor prognosis. Here, we characterized the prognostic effect of p-p38 in colorectal cancer (CRC). Three hundred and sixteen CRC patients in stages I-III were
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