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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 176 kDa
物種活性
rat, human, mouse
濃度
~1 mg/mL
技術
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pTyr1604)
基因資訊
human ... ALK(238)
一般說明
The anaplastic lymphoma kinase (ALK) gene codes for a transmembrane receptor tyrosine kinase (RTK) that has 1620 amino acids. It is a member of the insulin receptor superfamily and is usually expressed in nerve cells. ALK gene is mapped to human chromosome 2p23.2.
免疫原
The antiserum was produced against synthesized peptide derived from human ALK around the phosphorylation site of Tyr1604.
Immunogen Range: 1570-1619
Immunogen Range: 1570-1619
生化／生理作用
Anaplastic lymphoma kinase (ALK) has the ability to trigger Stat3 (signal transducer and activator of transcription 3) and rescue hematopoietic cells from cell death.Mutations in ALK-1 result in hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant disorder of localized angiodysplasia.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
Zamo A, et al.
Oncogene, 21(7), 1038-1047 (2002)
The role of anaplastic lymphoma kinase in pediatric cancers
Takita J, et al.
Cancer Science, 108(10), 1913-1920 (2017)
Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1
Lux A, et al.
The Journal of Biological Chemistry, 274(15), 9984-9992 (1999)
A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation
Lamant L, et al.
Blood, 93(9), 3088-3095 (1999)
Selective ALK inhibitor alectinib with potent antitumor activity in models of crizotinib resistance.
Tatsushi Kodama et al.
Cancer letters, 351(2), 215-221 (2014-06-03)
The clinical efficacy of the ALK inhibitor crizotinib has been demonstrated in ALK fusion-positive NSCLC; however, resistance to crizotinib certainly occurs through ALK secondary mutations in clinical use. Here we examined the efficacy of a selective ALK inhibitor alectinib/CH5424802 in
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