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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 84 kDa
物種活性
rat, human, mouse
濃度
~1 mg/mL
技術
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer176/pSer177)
基因資訊
human ... CHUK(1147) , IKBKB(3551)
一般說明
CHUK (conserved helix-loop-helix ubiquitous kinase) is located on human chromosome 10q24. IKK1/IKK-α has three ordered protein domains, namely, a kinase domain (KD), a ubiquitin-like domain (ULD) and a scaffold dimerization domain (SDD). IKKB (inhibitor of nuclear factor κ B kinase subunit β) is mapped to human chromosome 8p11. IKBKB codes for IκB kinase 2 (IKK2/IKKβ). IKK1 and IKK2 has a canonical MAP kinase kinase (MAPKK) activation loop motif.
免疫原
The antiserum was produced against synthesized peptide derived from human IKK-alpha around the phosphorylation site of Ser177.
Immunogen Range: 151-200
Immunogen Range: 151-200
生化／生理作用
IKK1/IKKα (I-κ-B kinase 1) modulates nuclear factor κ-B (NF-κB) signaling, that is required for lymphoid organogenesis and adaptive immunity. IκB kinase α (IKKα) plays a major role in human skin cancer. This gene also controls terminal differentiation and multiplication of keratinocytes. IKKβ acts as the master regulator of cell survival and the inflammatory response.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Structural Basis for the Activation of IKK1/α.
Polley S, et al.
Cell Reports, 17(8), 1907-1914 (2016)
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Reid M A, et al.
Genes & Development, 30(16), 1837?1851-1837?1851 (2016)
A suite of novel human spermatozoal RNAs.
Ostermeier G C, et al.
Journal of Andrology, 26(1), 70-74 (2005)
I?B kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway.
Xie Y, et al.
Oncology Reports, 34(5), 2225-2232 (2015)
Deficiency of innate and acquired immunity caused by an IKBKB mutation.
Pannicke U, et al.
The New England Journal of Medicine, 369(26), 2504-2514 (2013)
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