推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 126 kDa
物種活性
human
濃度
~1 mg/mL
技術
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TERT(7015)
一般說明
Anti-Telomerase Antibody detects endogenous levels of total Telomerase protein.
The TERT (telomerase reverse transcriptase) gene is mapped to human chromosome 5p15.33 and encodes for a ribonucleoprotein.
免疫原
The antiserum was produced against synthesized peptide derived from human Telomerase.
Immunogen Range: 796-845
Immunogen Range: 796-845
生化／生理作用
TERT (telomerase reverse transcriptase) catalyzes the de novo synthesis of telomere and results in cellular immortalization to maintain chromosomal stability. Mutations in TERT causes different types of malignancies such as gliomas, gastric cancer, and anaplastic thyroid cancer. Therefore, TERT serves as an early prognostic biomarker.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Silencing of hTERT blocks growth and migration of anaplastic thyroid cancer cells.
Maggisano V
Molecular and Cellular Endocrinology, 448, 34-40 (2017)
The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma.
Carkic J
Journal of Oral Science, 58(4), 449-458 (2016)
Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas.
Fan X
Journal of Neuro-Oncology, 28(3), 455-462 (2016)
Lung cancer susceptibility locus at 5p15.33.
McKay JD
Nature Genetics, 40(12), 1404-1406 (2008)
Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression.
Tang B
Oncotarget, 7(10), 11364-11379 (2016)
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