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Merck
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Key Documents

SAB4502770

Sigma-Aldrich

Anti-SHC antibody produced in rabbit

affinity isolated antibody

别名:

SH2 domain protein C1, SHC, SHC-transforming protein 1, SHCA, Src homology 2 domain-containing-transforming protein C1

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About This Item

MDL號碼:
MFCD01634176
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 62 kDa

物種活性

human, rat, mouse

濃度

~1 mg/mL

技術

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登錄號

P29353

UniProt登錄號

P29353

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... SHC1(6464)

一般說明

Anti-SHC Antibody detects endogenous levels of total SHC protein.

免疫原

The antiserum was produced against synthesized peptide derived from human Shc.

Immunogen Range: 393-442

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

nwg

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Santosh Kumar et al.
Biochemical and biophysical research communications, 449(4), 496-501 (2014-05-23)
Hypercholesterolemia leads to a prothrombotic phenotype. Platelet hyperactivity associated with hypercholesterolemia has been attributed, in part, to oxidative stress. P66Shc is a well-known determinant of cellular and organismal oxidative stress. However, its role in platelet biology is not known. We
M Halon et al.
Free radical research, 48(11), 1363-1370 (2014-09-02)
Recently, iron and the adaptor protein "p66Shc" have been shown to play an important role in the development of amyotrophic lateral sclerosis (ALS) in rats. We hypothesized that changes in muscle p66Shc activity and iron metabolism would appear before visible
Doris Mangiaracina Benbrook et al.
Investigational new drugs, 32(3), 412-423 (2013-11-21)
SHetA2 is a small molecule flexible heteroarotinoid (Flex-Het) with promising cancer prevention and therapeutic activity. Extensive preclinical testing documented lack of SHetA2 toxicity at doses 25 to 150 fold above effective doses. Knowledge of the SHetA2 molecular target(s) that mediate(s)

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