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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 83 kDa
物種活性
human, rat, mouse
濃度
~1 mg/mL
技術
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
proteolytically cleaved (Val1697)
基因資訊
human ... NOTCH2(4853)
一般說明
抗-NOTCH2(Cleaved-Val1697)抗体可检测激活的NOTCH2(Cleaved-Val1697)蛋白。
免疫原
针对人源 NOTCH2 的合成肽产生抗血清。
免疫原范围：1678-1727
免疫原范围：1678-1727
生化／生理作用
现已确知NOTCH2基因参与癌症细胞的增殖、细胞周期进展和集落形成。在肝细胞癌和唾液腺腺样囊性癌中观察到该基因上调。NOTCH2 的敲除增加了癌细胞对化疗药物（如5-氟脲嘧啶）的敏感性。NOTCH2在肝脏发育的调节中起重要作用。
特點和優勢
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
外觀
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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International journal of molecular sciences, 18(12) (2017-12-21)
The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully elucidated. Our studies of patient-derived pHGG tissues and of the pHGG cell line KNS42 revealed down-regulation in these tumors of three microRNAs, specifically miR-107, miR-181c
Domenica Giannandrea et al.
Haematologica, 107(9), 2183-2194 (2022-03-11)
Multiple myeloma (MM) is an incurable hematologic neoplasm, whose poor prognosis is deeply affected by the propensity of tumor cells to localize in the bone marrow (BM) and induce the protumorigenic activity of normal BM cells, leading to events associated
Kai Dai et al.
Frontiers in immunology, 8, 320-320 (2017-04-07)
The mechanisms by which tumor-responsive CD8+ T cells are regulated are important for understanding the tumor immunity and for developing new therapeutic strategies. In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid
Wen-Rui Wu et al.
Oncology reports, 36(1), 181-188 (2016-05-26)
The Notch pathway plays an important role in both stem cell biology and cancer. Notch2 was reported to be upregulated in human hepatocellular carcinoma (HCC) tissues. However, the biological function of Notch2 in human HCC cells has not yet been
Jing Qu et al.
Molecular and cellular biochemistry, 411(1-2), 135-141 (2015-10-03)
Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we
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