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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 100 kDa
antigen 130 kDa
物種活性
human, rat, mouse
濃度
~1 mg/mL
技術
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
應用
research pathology
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
proteolytically cleaved (Asp1733)
基因資訊
human ... NOTCH2(4853)
一般說明
Anti-NOTCH2 (Cleaved-Asp1733) antibody detects endogenous levels of fragment of activated NOTCH2 (Cleaved-Asp1733) protein.
免疫原
The antiserum was produced against synthesized peptide derived from human Notch 2.
Immunogen Range: 1684-1733
Immunogen Range: 1684-1733
生化／生理作用
The NOTCH2 (notch2) gene is known to be involved in the proliferation, cell cycle progression and colony formation of cancer cells. Upregulation of the gene is observed in hepatocellular carcinoma and salivary adenoid cystic carcinoma. Deletion of NOTCH2 increases the sensitivity of the cancer cells to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
W Zhao et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 24(8), 2275-2281 (2013-02-08)
The Hajdu-Cheney syndrome is a very rare disease that affects several organ system, leading to severe osteoporosis and other abnormalities. We describe clinical and genetic findings of nine patients with this disease. The Hajdu-Cheney syndrome (HCS) is a rare autosomal
You Zou et al.
Molecular medicine reports, 14(4), 3517-3524 (2016-08-31)
Notch signaling is important during the development of a variety of human tumors. Depending on the context, Notch signaling can be either oncogenic or anti‑proliferative, and therefore, its effects in cancer are unpredictable. The aim of the present study was
Wen-Rui Wu et al.
Oncology reports, 36(1), 181-188 (2016-05-26)
The Notch pathway plays an important role in both stem cell biology and cancer. Notch2 was reported to be upregulated in human hepatocellular carcinoma (HCC) tissues. However, the biological function of Notch2 in human HCC cells has not yet been
Jing Qu et al.
Molecular and cellular biochemistry, 411(1-2), 135-141 (2015-10-03)
Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we
Arjan J Groot et al.
Molecular and cellular biology, 34(15), 2822-2832 (2014-05-21)
In mammals, there are four NOTCH receptors and five Delta-Jagged-type ligands regulating many aspects of embryonic development and adult tissue homeostasis. NOTCH proteins are type I transmembrane receptors that interact with ligands on adjacent cells and are activated by regulated
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