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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 116 kDa
物種活性
human, mouse, rat
濃度
~1 mg/mL
技術
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LIPE(3991)
一般說明
Human hormone-sensitive lipase (HSL) gene, containing 9 exons and spanning ~11kB, is mapped to chromosome 19q13.3. HSL is majorly expressed in adipose and steroidogenic tissues, but expressed at low levels in heart and skeletal muscle, macrophages, and islets. Functional HSL exists as a homodimer with high hydrolytic activity. HSL is characterized with a C-terminal catalytic domain, regulatory module and an N-terminal domain responsible for protein–protein and protein–lipid interactions.
免疫原
The antiserum was produced against synthesized peptide derived from human HSL.
Immunogen Range: 520-569
Immunogen Range: 520-569
生化／生理作用
Hormone-sensitive lipase (HSL) is the major source of energy for most of the tissues. It plays a vital role in hydrolysis of triacylglycerol stored in adipose tissue and possibly steroidogenesis. HSL activity is regulated through reversible phosphorylation by catecholamines and insulin. HSL, also hydrolyzes cholesterol esters in the adrenals, ovaries, testes, and macrophages and plays an essential role in spermatogenesis. HSL mRNA expressed in islets might be implicated in glucose-induced insulin secretion. Abnormality in the protein expression results in obesity, atherosclerosis and type II diabetes.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Stephen J Yeaman
The Biochemical journal, 379(Pt 1), 11-22 (2004-01-17)
Although described initially as an intracellular adipocyte-specific triacylglycerol lipase, it is now clear that HSL (hormone-sensitive lipase) is expressed in multiple tissues and plays a number of roles in lipid metabolism, including that of a neutral cholesteryl ester hydrolase. The
Wucai Yang et al.
Scientific reports, 7(1), 15080-15080 (2017-11-10)
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan which is produced and secreted mainly by the pineal gland and regulates a variety of important central and peripheral actions. To examine the potential effects of melatonin on the proliferation and differentiation of
Fredric B Kraemer et al.
Journal of lipid research, 43(10), 1585-1594 (2002-10-05)
Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid and water soluble substrates. HSL activity is regulated post-translationally by phosphorylation and also by pretranslational mechanisms.
C Holm et al.
Science (New York, N.Y.), 241(4872), 1503-1506 (1988-09-16)
Hormone-sensitive lipase, a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin. The 757-amino acid sequence predicted from a cloned rat adipocyte complementary DNA showed no homology
J Osuga et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(2), 787-792 (2000-01-19)
Hormone-sensitive lipase (HSL) is known to mediate the hydrolysis not only of triacylglycerol stored in adipose tissue but also of cholesterol esters in the adrenals, ovaries, testes, and macrophages. To elucidate its precise role in the development of obesity and
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