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Key Documents

SAB4501720

Sigma-Aldrich

Anti-LAMA5 antibody produced in rabbit

affinity isolated antibody

别名:

α 5, laminin, laminin α 5, laminin α-5

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 399 kDa

物種活性

human, mouse

濃度

~1 mg/mL

技術

ELISA: 1:20000
immunohistochemistry: 1:50-1:100

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... LAMA5(3911)

一般說明

Anti-LAMA5 Antibody detects endogenous levels of total LAMA5 protein. Laminin alpha5 (LAMA5) codes for the laminin α5 chain. It is mapped to human chromosome 20q13.2- q13.3. In human skin, LAMA5 is produced and liberated by dermal pericytes.

免疫原

The antiserum was produced against synthesized peptide derived from human LAMA5.

Immunogen Range: 2381-2430

應用

Anti-LAMA5 antibody has been used in immunohistochemistry, immunocytochemistry and immunofluorescent staining.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

生化/生理作用

Furthermore, studies in mice showed that Lama5 is involved in organogenesis and placental function during pregnancy. LAMA5 may play a role in regulating inter-individual variability in metabolic phenotypes in children. It induces skin regeneration both in vitro and in vivo.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Common variants in the LAMA5 gene associate with fasting plasma glucose and serum triglyceride levels in a cohort of pre-and early pubertal children.
De Luca M, et al.
Journal of pediatric genetics, 1(4), 229-234 (2012)
A role for pericytes as microenvironmental regulators of human skin tissue regeneration.
Paquet-Fifield S, et al.
The Journal of Clinical Investigation, 119(9), 2795-2806 (2009)
Glícia Maria de Almeida et al.
Scientific reports, 5, 17860-17860 (2015-12-15)
Extracellular matrix (ECM) is known to play several important roles in vascular development, although the molecular mechanisms behind these remain largely unknown. RECK, a tumor suppressor downregulated in a wide variety of cancers, encodes a membrane-anchored matrix-metalloproteinase-regulator. Mice lacking functional
Jyoti Gautam et al.
Scientific reports, 6, 36450-36450 (2016-11-04)
Laminin, a major component of the basement membrane, plays an important role in blood brain barrier regulation. At the neurovascular unit, brain endothelial cells, astrocytes, and pericytes synthesize and deposit different laminin isoforms into the basement membrane. It has been

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