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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 112 kDa
物種活性
mouse, human
濃度
~1 mg/mL
技術
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... FLT3(2322)
一般說明
Anti-FLT3 antibody detects endogenous levels of total FLT3 protein.
FLT3 (Fms-like tyrosine kinase) is a member of tyrosine kinase (RTK) family. It has an extracellular domain consisting of five immunoglobulin-like domains and an intracellular kinase domain interrupted by a kinase insert. It is located on human chromosome 13q12.
免疫原
The antiserum was produced against synthesized peptide derived from human FLT3.
Immunogen Range: 565-614
Immunogen Range: 565-614
生化/生理作用
Mutation in FLT3 (Fms-like tyrosine kinase) results in acute myeloid leukemia and it also induces warburg effect and offers therapeutic sensitivity to glycolytic inhibition.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
nwg
閃點(°F)
Not applicable
閃點(°C)
Not applicable
ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition
Leukemia, 31(10), 2143-2143 (2017)
Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
Cellular and Molecular Life Sciences, 74(14), 2679-2688 (2017)
Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255
Cancer Research, 64(20), 7241-7244 (2004)
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