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Key Documents

SAB4500756

Sigma-Aldrich

Anti-APLF antibody produced in rabbit

affinity isolated antibody

别名:

APFL, C2orf13, Xip1, aprataxin and PNK-like factor

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 56 kDa

物種活性

human, mouse

濃度

~1 mg/mL

技術

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... APLF(200558)

一般說明

Aprataxin and PNKP-like factor (APLF) is also called as PALF and Xip1. It is located in the nucleus. APLF has a forkhead-associated (FHA) domain and two unique poly (ADP-ribose)-binding zinc finger (PBZ) domains in its C-terminal region. This gene is mapped to human chromosome 2p13.3.

免疫原

The antiserum was produced against synthesized peptide derived from human APLF.

Immunogen Range: 82-131

生化/生理作用

Aprataxin and PNKP-like factor (APLF) acts as a DNA repair factor. The forkhead-associated (FHA) domain of APLF helps to bind to the phosphorylated FHA domain binding motifs (FBMs) in XRCC1 and XRCC4. Other domains of APLF recruites APLF to sites of DNA damage.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Characterization of the APLF FHA?XRCC1 phosphopeptide interaction and its structural and functional implications.
Kim K, et al.
Nucleic Acids Research, 45(21), 12374-12387 (2017)
Identification and functional characterization of a Ku-binding motif in aprataxin polynucleotide kinase/phosphatase-like factor (APLF).
Shirodkar P, et al.
The Journal of Biological Chemistry, 288(27), 19604-19613 (2013)
Rapid whole genome sequencing identifies a novel GABRA1 variant associated with West syndrome.
Farnaes L, et al.
Cold Spring Harbor molecular case studies, 3(5), mcs-a001776 (2017)

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